Updating the sequence based classification of glycosyl hydrolases

Glycoside hydrolases are also referred to as glycosidases, and sometimes also as glycosyl hydrolases.

updating the sequence based classification of glycosyl hydrolases-1

Each of the resulting sequence-based families contain proteins that are related by sequence, and by corollary, three-dimensional fold.

A classification of glycoside hydrolases in families based on amino acid sequence similarities has been proposed a few years ago.

Because there is a direct relationship between sequence and folding similarities, such a classification: (i) reflects the structural features of these enzymes better than their sole substrate specificity, (ii) helps to reveal the evolutionary relationships between these enzymes, (iii) provides a convenient tool to derive mechanistic information) provides a continuously updated list of the glycoside hydrolase families. Liu QP, Sulzenbacher G, Yuan H, Bennett EP, Pietz G, Saunders K, Spence J, Nudelman E, Levery SB, White T, Neveu JM, Lane WS, Bourne Y, Olsson ML, Henrissat B, Clausen H (2007) Bacterial glycosidases for the production of universal red blood cells.

Glycoside hydrolases (EC 3.2.1.-) are a widespread group of enzymes which hydrolyse the glycosidic bond between two or more carbohydrates or between a carbohydrate and a non-carbohydrate moiety.

The IUBMB Enzyme nomenclature of glycoside hydrolases is based on their substrate specificity and occasionally on their molecular mechanism; such a classification does not reflect (and was not intended to) the structural features of these enzymes.

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